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KMID : 0364019950280050437
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Korean Journal of Thoracic and Cardiovascular Surgery
1995 Volume.28 No. 5 p.437 ~ p.442
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Effect of the Brain Death on Hemodynamic Changes and Myocardial Damages in Canine Brain Death Model -Hemodynamic and Electrocardiographic Changes in the Brain Death Model Caused by Sudden Iscrease of Intracranial Pressure-
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조명찬
김동운/이상수/강훈/임승운/김영규/노윤우/이조한/홍종면
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Abstract
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We developed an experimental model of brain death using dogs. Brain death was caused by increasing the intracranial pressure (ICP) suddenly by injecting saline to an epidural Foley catheter in five female mongrel dogs (weight, 20-25kg).
Hemodynamic
and
electrocardiographic changes were evaluated continuously during the process of brain death.
1. Abrupt rise of ICP after each injection of saline followed by a rapid decline to a new steady-state level within 15 minutes and the average volume required to induce brain death was 7.6*0.8ml.
2. Body temperature, heart rate, mean pulmonary arterial pressure, left ventricular (LV) enddiastolic pressure and cardiac output was not changed significantly during the process of brain death, but there was an increasing tendency.
3. Mean arterial pressure and LV maximum +dP/dt increased significantly at the time of brain death.
4. Hemodynamic collapse was developed within 140 minutes after brain death.
5. Marked sinus bradycardia followed by junctional rhythm was seen in two dogs and frequent VPB's with ventricular tachycardia was observed in one dog at the time of train death.
Hyperdynamic state develops and arrhythmia appears frequently at the time of brain death. Studies on the effects of brain death on myocardium and its pathophysiologic mechanism should be followed in the near future.
(Korean J Thorac Cardiovasc Surg 1995;28:437-42)
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